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学 术 论 文      

近年来在国际权威期刊上发表的主要学术论文:

1.

Wei Zhang et al. Inhibition of Calcium-Calmodulin-Dependent Kinase II Suppress Cardiac Fibroblast Proliferation and Extracellular Matrix Secretion  Journal of Cardiovascular Pharmacology  2010,55(1):96-105

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Wei Zhang et al. Ca2+calmodulin-dependent protein kinase IId orchestrates G-protein-coupledreceptor and electric eld stimulation-induced cardiomyocyte hypertrophy Clin Exp Pharmacol Physiol. 2010, 37(8)795–802

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Wei ZHANG et al. Effects of 2,3,4’,5-Tetrahydroxystilbene-2-0-β-D-glucoside on vascular endothelial dysfunction in atherogenic-diet rats  Journal of Medicinal Plant and Natural Product Research 2009,75:1209-1214

4.

Wei Zhang et al.2,3,4’,5-TETRAHYDROXYSTILBENE-2-O-β-D-GLUCOSIDE SUPPRESSES MATRIX METALLOPROTEINASE EXPRESSION AND INFLAMMATION IN ATHEROSCLEROTIC RATS. Clin Exp Pharmacol Physiol.200835(3):310-6.

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Li Zhu et al. Ginkgolide B preconditioning protects neurons against ischemia-induced apoptosis

 Journal of Cellular and Molecular Medicine, 20091311-12):4474-4483

6.

Li Zhu et al. Hypothermia attenuates protective effects of ginkgolides on astrocytes from ischemia/reperfusion injury

Neurochemistry International,200955181-186

7.

Li Zhu et al. Ginkgolides mimic the effects of hypoxic preconditioning to protect C6 cells against ischemic injury by up-regulation of hypoxia-inducible factor-1 alpha and erythropoietin. The International Journal of Biochemistry & Cell Biology,200840651-662

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Li Zhu et al. Expression of bystin in reactive astrocytes induced by ischemia/reperfusion and chemical hypoxia in vitro Biochim Biophys Acta, 20081782658-663

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Li Zhu et al. Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. Journal of Cellular and Molecular 2008122):569-579

10.

Li Zhu et al. Nerve Growth Factor Protects the Cortical Neurons from Chemical Hypoxia-induced Injury

 Neurochemical Research,200833784-789

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Li Zhu et al. Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway -dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Journal of cellular Biochemistry,  2008103564-575

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Yajun Zhou et al. PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARgamma gene expression inprimary rat hepatic stellate cell. Molecular and Cellular Biochemistry 2009, 325:131-139

13.

Yajun Zhou et al. Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro Life Sciences2009, 84:544-551

14.

Yajun Zhou et al.  The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARg in rat activated hepatic stellate cell in vitro. Laboratory Investigation 2007, 87(5):488-498

15.

Li Zhu et al. Synthesis of Peracetyl d-fucopyranosyl Bromide and Its Use in Preparation of Diphyllin d-fucopyranosyl Glycoside Journal of Carbohydrate Chemistry,200827113-119

16.

Li Zhu et al. Ginkgolides protect primary cortical neurons from potassium cyanide-induced hypoxic injury

Experimental Brain Research,2007179665-671

17.

Li Zhu et al. Up-regulation of HIF-1 expression induced by ginkgolides in hypoxic neurons

Brain Research,200711661-8

18.

Yajun Zhou et al.Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage. Mol Cell Endocrinol. 2010 29;323(2):193-200.

19.

Guoliang Meng et al. Synergistic Attenuation of Myocardial Fibrosis in spontaneously hypertensive rats by joint treatment with Benazepril and Candesartan J Cardiovasc Pharmacol 2009, 54(1): 16-24

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Gao YJ et al. nvolvement of P311 in the affective, but not in the sensory component of pain.Molecular Pain,2008423

21.

Zhang Wei et al. Effects of moxonidine versus clonidine on arterial pressure and heart rate in renal-hypertensive rats.Chinese Journal of Clinical Rehabilitation,2006,10(28):170-3

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Gao YJ et al.Activation of JNK pathway in persistent pain. Neuroscience Letters, 2008437180-183

23.

Gao YJ et al.Central serotonergic neurons are differentially required for opioid analgesia, but not for morphine tolerance and morphine reward. PNAS,2007, 104 (36): 14519–14524

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Gao YJ et al. Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to th induction and expression of affective pain. Journal of Neuroscience, 2009,29(10):3307–3321

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Gao YJ et al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain Journal of Neuroscience,2009, 29(13):4096–4108

26.

Gao YJ et al. Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model Experimental Neurology, 2009, 219:146–155

27.

Jiang ZL et al. Neuroprotective effect of taurine against focal cerebral ischemia in rats possibly mediated by activation of both GABAA and glycine receptors. Neuropharmacology, 2007521199-1209

28.

Jiang ZL et al. Ginsenoside Rg1 protects neurons from hypoxic–ischemic injury possibly by inhibiting Ca2+ influx through NMDA receptors and L-type voltage-dependent Ca2+ channels. European Journal of Pharmacology, 200858690-99

29.

Jiang ZL et al.. Inhibition of NMDA receptors underlies the neuroprotective effect of ginsenoside Rb3. American Journal of Chinese Medicine ,200937,(4759-770

30.

Shen HM et al.The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA receptors. Brain Research Bulletin,200877274-281

31.

Xu XL et al.Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo. Eur J Pharmacol. 2007 Jul 30;568(1-3):203-12. Epub 2007 Apr 19.

32.

Xu XL et al. Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase. Pharmacology. 2008;81(4):325-32. Epub 2008 Mar 18.

33.

Xu XL et al..Cardioprotective effects of Astragali Radix against isoproterenol-induced myocardial injury in rats and its possible mechanism. Phytother Res. 2008 Mar;22(3):389-94.

34.

Lou lin et al. Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta 1 in rats with carbon tetrachloride-induced liver injury. J GASTROEN HEPATOL2009,24(6): 1070-1076

35.

Cen X et al. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat. Molecular and Cellular Biochemistry.2009,332(1-2), 85-93

36.

Cen X et al. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain research 2008,1238, 189-198

37.

Wang DG et al. Tissue Distribution and Excretion of Resveratrol in Rat after Oral Adminstration of Polygonum Cuspidatum Extract . Phytomedicine 200815859–866.

38.

Guangtong Chen et al. Comparative analysis on microbial and rat metabolismof ginsenoside Rb1 by high-performance liquidchromatography coupled with tandem mass spectrometry. Biomed. Chromatogr. 200822: 779–785

39.

Guangtong Chen et al.Comparative Analysis of Microbial and Rat Metabolism of the  Total Saponins from Panax notoginseng by HPLC-ESI-MS/MS. Natural Product Communications  20083 (5)661-667

40.

Guangtong Chen et al.Microbial Transformation of 20(S)-Protopanaxatriol-Type Saponins by Absidia coerulea. Journal of Natural Products, 2007707):1203-120

41.

Guangtong Chen et al. Microbial transformation of ginsenoside Rb1 by Acremonium strictum. Appl Microbiol Biotechnol (2008) 77:1345–1350

42.

Zhu WZ et al.Activation of CaMKII-delta C is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. J Biol Chem. 2007, 282 (14): 10833-9.

43.

Zhu WZ et al.Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res. 2007 100(3):399-407

44.

Weizhong Zhu et al. Rui-Ping Xiao, Darrell R. Abernethy, and Irving W. Wainer. Comparative Molecular Field Analysis of the Binding of the Stereoisomers of Fenoterol and Fenoterol Derivatives to the 2 Adrenergic Receptor J. Med. Chem. 2007; 50(12) pp 2903 - 2915

45.

Zhu WZ et al. Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality. 2006 Nov;18(10):822-7.

47.

Zhu WZ et al. Calmodulin kinase II inhibition protects against myocardial apoptosis in vivo by phospholamban-dependent and –independent mechanisms  AJP 2006; 291(6): H3065-75

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Chen li et al. Association of NET-1 gene expression with human hepatocellular carcinoma Int J Surg Pathol2007:15;346-352

Chen li et al.Clinicopathological significance of overexpression of TSPAN1, KI67 and CD34 in gastric carcinoma Tumori 2008,94: 531-538

Chen li et al.Developmental Regulation of SSeCKS Expression in Rat Brain  J Mol Neurosci2007 639-15

 

Chen li et al. Spatiotemporal expression of SSecks in Injured Rat Sciatic Nerve The anatomical record  2008,291:527-537

Chenli et al. Roles of Cortactin, an Actin Polymerization Mediatorin Cell Endocytosis Acta biochimica et biophysica sinica 2006, 38(2),95-103

 

Deng Fu Yao et al. Delayed hepatocarcinogenesis through antiangiogenic intervention in the nuclear factor-kappa B activation pathway in rats. Hepatobiliary Pancreat Dis Int 2010; 9: 169-174

 

Deng Fu Yao et al.Abnormal Expression of Hepatoma Specic g-Glutamyl Transferase and Alteration of g-Glutamyl Transferase Gene Methylation Status in Patients with Hepatocellular Carcinoma. American Cancer Society 15, 2000 88 761-769

 

Deng Fu Yao et al.Quantitative analysis of hepatic hypoxia-inducible factor-1α and its abnormal gene expression during the formation of hepatocellular carcinoma. (Hepatobiliary Pancreat Dis Int 2009; 8: 407-413

 

Deng Fu Yao et al. Clinical impact of plasma TGF-β1 and circulating TGF-β1 mRNA in diagnosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2008; 7: 288-295

 

Deng Fu Yao et al. Impaired long-chain fatty acid metabolism in mitochondria causes brain vascular invasion by

a non-neurotropic epidemic inuenza a virus in the newborn/suckling period: Implications for inuenza-associated encephalopathy. Molecular and Cellular Biochemistry 2007 299: 85–92

 

Wenjuan Yao et al. Display of -amylase on the surface of Corynebacterium glutamicum cells by using NCgl1221 as the anchoring protein, and production of glutamate from starch.Arch Microbiol (2009) 191:751–759

 

Wenjuan Yao et al. Double deletion of dtsR1 and pyc induce eYcient L-glutamate overproduction in Corynebacterium glutamicum. J Ind Microbiol Biotechnol (2009) 36:911–921

 

Wenjuan Yao et al. Expression and localization of theCorynebacterium glutamicum NCgl1221 protein

encoding an L-glutamic acid exporter. Microbiological Research 164 (2009) 680—687